PaO2/FiO2 increased and lactate decreased by HES 200/0.5 but not albumin (p < 0.05 for both comparisons); higher cardiac index, DO2I and VO2I in HES 200/0.5 group (p < 0.05 for all comparisons); no differences in incidence of renal failure, platelet count, PT or aPTT. This evidence concerns the gene F2 and Renal insufficiency.