MUC2 and colitis: Muc2−/− show neo-expression in the colon of the Muc6 gastric mucin [22], whereas, similar to UC [65], Muc6 was not expressed by Winnie and Eeyore. Muc2 deficiency causes increased mitosis/crypt hyperproliferation [21] and, on a 129/Sv background but not a C57BL/6J × 129/Sv background, growth retardation, diarrhoea, occasional rectal prolapses, focal erosions, and mild inflammation in the distal colon and increased susceptibility to DSS-induced colitis [22].