Because of the small number of studies on the real effects of oral contraceptives on breast fibroadenomas, we proposed to evaluate the cellular proliferation of this epithelium tissue according to its expression of cellular proliferation proteins (Ki-67 and c-myc) among users of oral contraceptives, with or without association with estriol, in order to investigate their effects on these tumors. This evidence concerns the gene MKI67 and Fibroadenoma.