Their involvement might be affected by many physiological factors,including the nature of the target organ and the magnitude of inflammation.Indeed, some autoimmune diseases are caused by IL-10 deficiency (e.g., colitis)[53, 54], whereas other autoimmune diseases are IL-10-independent (e.g.,gastritis) [55] and/or -dependent on TGF-β deficiency(e.g., diabetes) [56]. This evidence concerns the gene TGFB1 and hyperinsulinemic hypoglycemia, familial, 4.