The biological significance of TREM-1 in acute inflammatory responses is documented in mouse models for septic shock, where competition of TREM-1 with a recombinant soluble TREM-1 fusion protein or anputative receptor blocking peptide derived from a conserved region of TREM-1 savedmice from lethal LPS challenge or bacterial sepsis [15–17]. Here, TREM1 is linked to bacterial infectious disease with sepsis.