Also increased levels of TNF-α, IL-6, IL-8, C-reactive protein, and fibrinogen in serum can be detectedin serum of patients with stable COPD and some of these systemic inflammatorychanges seem to be related to disease severity [4] and correlate with severity ofsystemic consequences like muscle wasting [40]. This evidence concerns the gene IL6 and chronic obstructive pulmonary disease.