Indeed, increased MIF plasma or serum levels were identified in patients with severe sepsis [8], Crohn's disease and ulcerative colitis [9], acute pancreatitis [10],rheumatoid arthritis (RA) [11], type 2 diabetes (T2D) [12], Guillain-Barresyndrome [13], or multiple sclerosis [14]. This evidence concerns the gene MIF and type 2 diabetes mellitus.