COX-2 expression is up-regulated in numerous pathologies including those of the reproductive tract such as ovarian carcinoma, cervical carcinoma and endometrial adenocarcinoma (Dore et al., 1998; Tong et al., 2000; Jabbour et al., 2001; Sales et al., 2001, 2002). The gene discussed is PTGS2; the disease is ovarian carcinoma.