MAPK3 and endometrium adenocarcinoma: In conclusion, our data provide strong evidence that the elevated biosynthesis of PGE2 and PGF2α produced locally within endometrial adenocarcinomas can act in an autocrine/paracrine manner to enhance the expression of COX-2 via the CRE by means of their integrative actions on intracellular signaling pathways such as the ERK1/2 pathway.