Based on a multi-institutional sample set larger than most prior studies, we found that univariate predictors of NSLN status include tumor size (in cm and by AJCC T size classification), tumor grade, hormone receptor status (ER and PR), angiolymphatic invasion, size of SLN metastasis, and whether nodal tumor involvement is identified by H&E. The gene discussed is NR4A1; the disease is neoplasm.