For example cross-linking of inhibitory receptor protein 60 (IR-p60)/CD300a inhibits mast cell and eosinophil activation and co-aggregation of CD300a with CCR3 using a bi-specific antibody fragment (LC1) has been shown to be effective in an animal model of asthma [77], but is still untested in human asthma. The gene discussed is CD300A; the disease is asthma.