Many studies indicate a critical role for GATA-3 in the development of airway eosinophilia, mucus hypersecretion and airway hyperesponsiveness in animal models of asthma [114] and suggest that local delivery of GATA-3 antisense oligonucleotides may be a novel approach for the treatment of asthma [115]. The gene discussed is GATA3; the disease is Increased total eosinophil count.