TNF-α was one of the earliest cytokines implicated in the pathogenesis of lung fibrosis diseases and, together with IL-1, has been found to over-expressed in regenerated type II pneumocytes in human lung, thus enhanced fibroblast proliferation [16]TNF-α polymorphisms have been discovered significantly associated with increased risk of developing pulmonary fibrosis [17, 18]. Here, TNF is linked to pulmonary fibrosis.