Other groups have demonstrated significant reduction of cancer pain with systemic NGF antagonism in murine models [16,21] While NGF may mediate these effects, in part, by inducing cancer cells to invade the perineurium, a great deal of evidence suggests that NGF may directly induce hypersensitivity in sensory neurons in both in vitro and in vivo models of neuropathic pain [22,23]. The gene discussed is NGF; the disease is cancer.