The results presented here show that gliadin toxicity, as measured by autoantibody secretion, decrease in ECH and increase in the density of lamina proprial CD25+ cells, can be demonstrated in the treated celiac disease patient organ culture system only if small-intestinal mucosal TG2-specific IgA autoantibody deposits are still present in the cultured biopsy samples. The gene discussed is CD79A; the disease is celiac disease.