INS and polycystic ovary syndrome: This PPARG SNPwas extensively studied, following initial reports that it was stronglyassociated with bodyweight and insulin sensitivity [41], and the effect of the Ala12 mutation on PCOS symptoms has beenclosely studied, although some specific conclusions are difficult to reach.There are conflicting reports regarding the effect of this allele on BMI:either linked with increased BMI [45, 52–55],lower BMI [41, 56–59], or not associatedat all [45, 60–64].