TheT allele is also more common in women with PCOS compared to non-PCOSBMI-matched controls [45], and thereforehas suspected involvement in the high incidence of obesity in PCOS population.However, both PCOS subjects and controls with T allele appear to be protectedfrom other complicating symptoms of obesity, having better insulin sensitivityin addition to lower circulating testosterone. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.