As PPARG is able, and required, to regulate many ofthese actions, it is important that the roles of PPARG be carefully consideredas new concepts develop regarding the effects of dietary supplements such asPUFAs, which are PPARG ligands, and the consequences of increased immunologicalactivation, such as occurs during obesity. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.