As thehealth crisis surrounding the obesity epidemic widens to include the damagingeffects on female fertility, it is important to remember the systemicimplications of metabolism and immune regulation on female fertility, and toconsider the role of PPARG in coordinating these contributions.Tremendous opportunity exists for those interested in elucidating further theexciting interactions between PPARG and female fertility. The gene discussed is PPARG; the disease is obesity disorder.