Whilst other adipokines such as visfatin and retinol-binding protein4 (RBP-4) are also linked withinsulin sensitivity [142, 143] and the incidence of PCOS [144, 145], leptin and adiponectin are ofparticular interest to those investigating female reproduction as it is known their presence can be detected byovarian cells which express leptin and adiponectin receptors. The gene discussed is LEP; the disease is polycystic ovary syndrome.