The beneficial effects of TZDs on ovarian PCOS symptoms were first attributed toimprovements in defective insulin action and secretion [92].However, actions upon various ovarian cells directlyillustrated both in vitro [1, 9, 14, 98, 99] and in vivo [100, 101] confirms a direct interaction between these compounds and ovarianPPARG. This evidence concerns the gene INS and polycystic ovary syndrome.