Carey et al. reported on the prevalence of IHC subtypes in correlation with survival in 469 early stage breast cancer patients in the pre-trastuzumab era with a minimum of 8.1 years of follow-up; in this study, the shortest survival was observed in patients with HER2+/ER- tumors (52%) in contrast to 75% in the basal-like subtype, 84% in luminal A, and 87% in luminal B [12]. The gene discussed is ERBB2; the disease is breast cancer.