FatiGO+ analysis showed that tumor libraries had significantly more expressed genes related to "cell organization and biogenesis" (GO:0016043), KRT7, PDIA3, PPGB and TRAPPC5 (p = 0.005); and "ligase activity" (GO:0016874), UBE2S and MTHFD1 (p = 0.028) than normal libraries,. The gene discussed is MTHFD1; the disease is neoplasm.