In this study we demonstrated that the administration of RG or LST to diet-induced atherosclerosis susceptible mice fed a HFHC diet preserves to the same extent in both groups the activity of nuclear receptor PPARγ Conclusions derived from the analysis of the expression levels of PPARγ responsive gene SCARB1 and the amplification levels of PPRE binding sites of target genes amplified after ChIP which were shown to be approximately equal. Here, SCARB1 is linked to atherosclerosis.