Until more recently, the conventional treatment of estrogen/progesterone receptor (ER/PgR) positive breast cancer in elderly postmenopausal women consisted primarily of surgery, followed by adjuvant endocrine or sequential chemo-endocrine therapy, and radiotherapy, depending on type of surgery (mastectomy or breast conservation), tumor volume and lymph node involvement [1]. This evidence concerns the gene ESR1 and breast carcinoma.