TGFB1 and scleroderma: To accomplish this, we first formulate a regulatory network involving TGFBRII, CTGF, SPARC, COL1A2, COL3A1 and TIMP3 as a biological system that is associated with TGF-β signaling, and then apply mathematical methods and computational algorithms from engineering and control theory [13] to perform dynamic analysis of this network for both normal and scleroderma fibroblasts in response to perturbation of environmental Stimuli.