To determine whether a similar skewing of DC capacity to prime CD8+ T cell responses extended to other influenza viruses and to explore whether this was also the case for CD4+ T cells we analysed the ability of pDC, CD8 DC and DN DC to prime influenza-specific MHC class I (CL4) and class II (HNT) in mice infected by intravenous (i.v.)inoculation two days previously with influenza PR8. Here, CD4 is linked to influenza.