INS and Insulin resistance: Fat fed mice exhibited some evidence of insulin resistance as increased insulin secretion was associated with glucose tolerance which was either deteriorated (C57BL/6, 129S6) or unchanged (BALB/c, DBA/2, C3H), and adiposity indices either increased (129S6 BALB/c, C3H) or were unchanged (C57BL/6, DBA/2).