GRIN2B and Tinnitus: Usingthis paradigm, we demonstrated that local cochlear application of ifenprodil, an antagonist of the 2Bsubunit of the NMDA receptor (NR2B), prevents the long-term occurrence of noise-induced tinnitus,suggesting that the 2B subunit ofthe NMDA receptor complex (NR2B) may be critically involved in the induction oftinnitus by salicylate.