NOS3 and myocardial infarction: Genetic polymorphisms of eNOS have been shown to have a significant effect on NO levels, plasma lipids and have been associated with T2DM [5], heart failure [6], coronary spasm [7], atherosclerosis [8], myocardial infarction [9], coronary in-stent restenosis [10] and hypertension [9] in some studies.