Other variables were entered into the model but were excluded by the stepwise regression: age (dichotomized by the median), sex, BMI>30, diabetes mellitus, hypertension, hyperlipidemia, myocardial infarction, family history of early heart disease, treatment with ACE inhibitors, β blockers, calcium channel blockers, AT1 blockers, or lipid lowering agents (Table 2). The gene discussed is ACE; the disease is Hypertension.