Most of the significantly up-regulated genes were involved in cell cycle/mitosis/cell division (e.g., TTK, CENPF, NEK2), while many of those down-regulated were involved in cell adhesion/cell cycle arrest (e.g., ADRB2, APLP2, MACF1), consistent with a role of these genes in neoplasia development. The gene discussed is NEK2; the disease is neoplasm.