These genes, such as NEK2[11], [12] and CENPF[11] (both on 1q32-q41), TPX2[13], [14] and STK6 (or AURKA)[15] (related to the Aurora-A activation pathway important in tumor progression[16]), TTK (linked to cell mitosis through EGFR,[17] a critical drug target for lung adenocarcinoma[18]), and BIRC5 (Survivin),[19] have all been found over-expressed in smoking-related tumors. This evidence concerns the gene BIRC5 and lung adenocarcinoma.