However, it failed to detect inclusions in some tauopathies, including the neuronal deposits in a case of FTDP-17T with the P301L mutation in Tau. Subsequently, (trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), a fluoro derivative of BSB, was shown to be a more sensitive probe than BSB for detecting β-amyloid deposits in tissue sections and in vivo [15,16] and for detecting tau inclusions in AD brain [15]. This evidence concerns the gene MAPT and Alzheimer disease.