TCF7L2 and type 2 diabetes mellitus: Polymorphisms of the TCF7L2 gene demonstrate the strongest and most reproducible association with type 2 diabetes of any gene reported to date; recent large-scale meta-analyses by Florez [12] and Cauchi et al. [13] reveal associations between the TCF7L2 SNP rs7903146 and type 2 diabetes with p values of < 10-80 and ~10-140 respectively.