INS and Hyperglycemia: Our observation that hyperglycaemia induced lower mRNA levels of NFKBIA, which encodes the NF-κB-inhibitor protein ‘inhibitor of kappa-Bα’ (IκBα), is in line with observations that IκBα protein levels decreased in healthy humans after an oral glucose load, although in this last study insulin levels were not suppressed by somatostatin [36].