These tumours are thought to originate from a multipotential mesenchymal cell type and are correlated with translocations between chromosomes 1 or 2 and chromosome 13, resulting in the generation of Pax3- or Pax7- forkhead (Pax3-7/FKHR) chimaeric genes [53,54]. The gene discussed is FOXO1; the disease is neoplasm.