Our results on the ASE-1 G-21A and ERCC1 Asn118Asn polymorphisms and risk of colorectal cancer are comparable to other cancer studies, where no associations have been observed between the two polymorphisms and risk of basal cell carcinoma, post-menopausal breast cancer and testicular cancer [2,31,35]. The gene discussed is ERCC1; the disease is breast carcinoma.