Aortic constriction causes more profound cardiac hypertrophy inheterozygous PPAR-γ knockoutmice than wild-type controls, further indicating the involvement of PPAR-γ in cardiac growth [77].Nuclear Factor-Kappa Beta (NF-κB) pathway is at least partially mediating theinhibition on hypertrophic growth in vitro [76]. Here, PPARG is linked to cardiac hypertrophy.