Pro467Leu, Val290Met, Phe388Leu, and Arg425Cysare all loss-of-function mutations (dominant negative) and have been associatedwith partial lipodystrophy, insulin resistance, diabetes, and hypertension [59–62], although it is not known whether theelevated blood pressure is due to impaired insulin sensitivity. The gene discussed is INS; the disease is hypertensive disorder.