TZDs have been shown toreduce superoxide generation and inhibit the expression of vascular celladhesion molecule-1, intercellular cell adhesion molecule-1, and lectinlikeoxidized LDL receptor, and hence inhibit inflammation in endothelial cells [103–106], suggesting an important roleof endothelial PPAR-γ in thedevelopment of atherosclerosis. The gene discussed is PPARG; the disease is atherosclerosis.