One of the physiologic systems that appears to have evolved tosustain this metabolic regulation is mediated by peroxisome proliferator-activated receptors (PPARs).In clinical pregnancy-specific disorders, including preeclampsia, gestational diabetes, and intrauterine growth restriction, aberrant regulation of components of the PPAR system parallels dysregulation of metabolism, inflammation and angiogenesis. Here, PPARA is linked to preeclampsia.