There is good evidence showing that bothPPAR-β/δ and PPAR-γ regulate theexpression of the genes involved myogenesis.Targeted expression of an activated form of PPAR-β/δ in the skeletal muscles of mice makes the animals resistantto obesity by increasing the numbers of oxidative muscle fibres [40], while theselective ablation of PPAR-β/δ inducesobesity by reducing the oxidative capacity of the muscles [41]. Here, PPARD is linked to obesity due to melanocortin 4 receptor deficiency.