Ets-1 is an early responsegene that mediates a variety of growth signals in neointimal SMCproliferation [74]; and atherosclerosis [75] and PPARγ ligands have been reported to inhibitEts-1 expression [76].The relevance of telomerase as target for PPARγ wasfurther demonstrated in SMCs overexpressing telomerase, in which the efficacyof PPARγ ligand pioglitazone to inhibit cellproliferation is lost [19]. This evidence concerns the gene PPARG and atherosclerosis.