AMD involves theabnormal retinal pigment epithelium (RPE), drusen formation,photoreceptor atrophy, and choroidal neovascularization.Peroxisome proliferator-activated receptors (PPARs) play animportant role in lipid degeneration, immune regulation,regulation of reactive oxygen species (ROSs), as well asregulation of vascular endothelial growth factor (VEGF),matrix metalloproteinase-9 (MMP-9), anddocosahexaenoic acid (DHA). This evidence concerns the gene VEGFA and age-related macular degeneration.