This intricate relationship demonstrates that PPARγ downregulates MMP expressionand inhibits MMP-9’s subsequent accumulation in Bruch’s membrane where it mayplay an integral role in the degradation of the extracellular matrix and be astimulus for migration of the RPE into Bruch’s membrane, in this waycontributing to the pathophysiology of AMD. Here, MMP9 is linked to age-related macular degeneration.