Toevaluate the potential of hexarelin to regulate cholesterol metabolism in vivo,apolipoprotein E (apoE)-null mice maintained on a long-term high-fat and high-cholesteroldiet, a condition known to promote atherosclerosis, showed a significantregression in plaque formation when treated with hexarelin compared tosaline-treated controls [67]. This evidence concerns the gene APOE and atherosclerosis.