Our group has recently demonstrated thatgemfibrozil treatment was associated with attenuation of diabetes-associatedMMP-2 and MMP-9 gene expression in aorta of diabetic apoE KO mice [8].Furthermore, studies in patients with type 2 diabetes and CVD have shown thattreatment with a PPARγ agonist isassociated with a reduction in plasma MMP-9 levels [11]. This evidence concerns the gene MMP9 and diabetes mellitus.