The expression of NGF,neurotrophin-4, low-affinity receptor for NGF, PACAP receptor expression, aswell as NEP activity did not differ between pruritus and nonpruritus group [8].Interestingly, Remröd et al. [11] did not find any relationship between SP-positivefibers nor cells and the degree of pruritus, but the analyzed group of patientsin this study was very small. Here, NGF is linked to Pruritus.