IL-12 reached amaximum in CIN II and decreased in CIN III and carcinoma; but the differencesbetween groups were statistically not significant (K. W. test: P=.068 for IL-12 + p40,P=.264 for IFNγ, P=.077 for TNFα and P=.071 for IL-2). The gene discussed is TNF; the disease is uterine cervix carcinoma in situ.