While it would be premature to proffer gluten-sensitive macaques as a bona fide animal model for celiac disease absent evidence of MHC (Mamu) class II association and of TG2 involvement, the gluten-inducible nature of signs and symptoms in these macaques provides an excellent in vivo system for studying oral glutenase efficacy as well as intestinal permeability toward gluten peptides under varied states of intestinal disrepair. This evidence concerns the gene TGM2 and celiac disease.