MBNL1 function is also impaired in myotonic dystrophy (DM), a multisystemic disease characterized by myotonia, cataracts and muscle weakness (reviewed in [4], [5]), and a fly model of spinocerebelar ataxia 8 genetically interacted with Drosophila muscleblind mutants [6]. The gene discussed is MBNL1; the disease is myotonic dystrophy.