The polymorphisms in the IRF5 gene that we found to be associated with MS in our study are not strongly correlated (r2 0.1–0.2) with the SNP rs10488631 or its proxies in the TNPO3 gene,34 indicating that it actually is IRF5, and not TNPO3, that is primarily responsible for the association with MS that we observe. This evidence concerns the gene TNPO3 and myeloid sarcoma.