PCT is a 116-amino acid pro-hormone, which have been shown to be an extremely useful marker in sepsis, whether blood cultures are positive or negative; and in sepsis-like conditions such as severe burns, pancreatitis, inhalation injury, severe mechanical trauma after extensive surgery, and also in some infections of nonbacterial causation as severe malaria or systemic fungal infection [31,37-40]. The gene discussed is CALCA; the disease is Sepsis.