Analysis of the activation status of the AKT/mTOR pathway by the detection of phosphorylated forms of each of the individual components showed that 129/166 (78%), 39/97 (40%), 23/107 (21%) and 87/146 (46%) of the RCC patients stained positive for pAKT, pmTOR, pS6 and p4E-BP1, respectively. The gene discussed is AKT1; the disease is renal cell carcinoma.