While the regulation of the mTOR pathway by AKT was not examined in the latter study, several lines of investigation provide data to indicate that this is highly probable and that analogous mechanisms also occur in RCC given that PP1 has recently shown to have important growth inhibitory properties in RCC-derived cell lines (Fujimoto et al, 2006; Hagiwara et al, 2006). The gene discussed is AKT1; the disease is renal cell carcinoma.