Although we have not yet examined the correlation between activated ERK1/2 and caveolin-1 in RCC, clearly, the ERK1/2 pathway appears to converge on the mTOR pathway in RCC, given that specific inhibitors of EGFR sensitise RCC cell lines to the effects of rapamycin (Costa et al, 2007). The gene discussed is EGFR; the disease is renal cell carcinoma.