Regarding the subcellular localisation of pan-survivin protein, the Ki-67 proliferation index was significantly higher in tumours with a positive expression of nuclear pan-survivin than in tumours with a negative expression of nuclear pan-survivin (52.4±26.5 vs 38.5±26.6, P=0.0047, Figure 4D). The gene discussed is BIRC5; the disease is neoplasm.