The cellular function of Ki-67 protein is still unclear, but depletion of Ki-67 protein by antisense oligonucleotides directed against Ki-67 mRNA leads to an inhibition of cell proliferation and tumour growth, suggesting that Ki-67 protein is functionally involved in cell cycle progression and may be a potential target in anticancer therapy (Kausch et al, 2003). Here, MKI67 is linked to neoplasm.