To examine the effect of SFRPs on Wnt signalling in breast cancer, we used a TCF/LEF-responsive reporter (pGL3-OT) to analyse the basal TCF/LEF transcriptional activity in seven breast cancer cell lines (MCF-7, MDA-MB-231, MDA-MB-435S, MDA-MB-436, MDA-MB-468, T-47D and SK-BR-3). The gene discussed is HNF4A; the disease is breast cancer.