SFRP1 and breast carcinoma: On the basis of their expression array analysis of chromosome 8p11–21 genes, Ugolini et al (1999) reported that expression of SFRP1 mRNA is frequently diminished or lost in breast carcinomas, and they also found that loss of SFRP1 occurs in more than 80% of invasive breast carcinomas, although not in the medullary type (Ugolini et al, 2001).