AKT2 and ovarian carcinoma: To further ascertain the role of Akt2 in the regulation of mitochondrial AIF translocation in CDDP-induced apoptosis in ovarian cancer cells, we extended these observations with a concentration–response (0, 2.5, 5, and 10 μM) study using the chemoresistant ovarian cancer cell line C13* and C13*-DNAkt2 cells, which are C13* cells stably transfected with dominant-negative Akt2 (T308A, S473A).