To determine if Akt regulates CDDP-induced AIF translocation, chemosensitive ovarian cancer cells (A2780s) stably transfected with constitutively active Akt2 (myristoylated wild-type Akt2; A2780s-AAkt2) were cultured with different concentrations of CDDP (0, 2.5, 5, and 10 μM). The gene discussed is AKT2; the disease is ovarian carcinoma.