In the mouse model of asthma, C57BL/6 wild type, NPRA-/- and NPRC-/- knockout mice were sensitized intraperitoneally (i.p.)with ovalbumin (OVA), the allergen used in the mouse model of allergic asthma, and then challenged with OVA intranasally (i.n.). Here, NPR3 is linked to allergic asthma.