BCL2L11 and Splenomegaly: Thus, loss of Bim and Fas do not cooperate to cause abnormalities in the thymus, demonstrating that the enhanced lymphadenopathy and splenomegaly seen in Bcl2l11−/−Faslpr/lpr and Bcl2l11+/−Faslpr/lpr mice are a consequence of defects in peripheral lymphoid organs.