DSG3 and acquired polycythemia vera: In the serum of PV patients, high titers of circulating autoantibodies targeting the epidermal adhesion molecule desmoglein 3 (Dsg3), one of the keratinocyte transmembrane proteins localized in the desmosome, which is essential for maintaining the integrity of the epidermis, are believed to cause clinical disease by direct binding to and disruption of desmoglein proteins [1,9].